Mean Serum Concentration of Vitamin D-binding Protein (Gc Globulin) Is Related to the Gc Phenotype in Women | Clinical Chemistry
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چکیده
Gc is the major carrier protein of vitamin D and its metabolites in the circulation and is important for preservation of the vitamin (4)(5). Gc also transports components such as fatty acids and endotoxin (6)(7), and it is an important player in the actin scavenging system (8)(9). Gc binds actin released from cells upon injury, and the Gc-actin complexes are rapidly cleared from the circulation, thereby preventing the harmful effects of actin filaments in blood vessels. The resulting decrease in Gc concentration makes Gc usable as a prognostic indicator of survival of patients with significant tissue injury after trauma (10) and among patients with hepatic failure (11). Vol. 47, Issue 4 April 2001 Table of
منابع مشابه
Mean serum concentration of vitamin D-binding protein (Gc globulin) is related to the Gc phenotype in women.
cause mild overtreatment, i.e., a reduction in dietary Phe allowances in excess of metabolic tolerance. This is not critical with Phe concentrations at or above the upper limit of normal. Still, neurological outcome has also been demonstrated to be adversely affected by Phe deficiency (14 ). In view of an overestimation by up to 60 mmol/L in the low concentration range and a target range of 40–...
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